The fight against wrinkles – rejuvenation is the latest trend in skincare

Does skincare really help against wrinkles? What the science says

February 11, 2025

Wrinkles – an unavoidable process or actually controllable?

Hardly any topic preoccupies people over 30 as much as skin aging. The first glance in the mirror each morning often shows it mercilessly: fine lines around the eyes, forehead wrinkles, crepey lines on the décolleté – they seem to become more visible by the day. Everyone experiences the natural aging process of the skin. But how fast and how strongly wrinkles develop isn't determined by genetics alone. External factors like UV radiation, oxidative stress and moisture loss play a decisive role.

Many people have already tried a wide range of anti-aging products for a lot of money – without visible results. The market is full of creams and serums that promise short-term effects but often show no lasting impact. So the big question remains: Can skincare really reduce wrinkles?

Scientists at Fraunhofer IPA researching skinmade, Stuttgart 2018

Many believe that skin aging is exclusively genetic and cosmetic products only deliver short-term effects. Others think that moisture alone is enough to prevent wrinkles. The answer lies in science. After more than 10 years of intensive research at the renowned Fraunhofer Institute, one of Europe's leading research institutions, skinmade® introduced a completely new skincare approach: Personalized care with scientifically proven active-ingredient complexes & penetration systems can visibly slow the aging process and reduce existing wrinkles. 

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But why do wrinkles form in the first place? And which approaches really work?

Why do wrinkles form – and which factors accelerate skin aging?

Wrinkles form through a combined effect of genetic predisposition and environmental factors. While our genes determine how quickly our skin ages, external factors play a decisive role in wrinkle formation. Wrinkles are the visible result of a combination of several biological processes taking place in the skin. While genetic disposition plays a role, it's mainly external influences and lifestyle that determine how quickly wrinkles form and how deep they are.

 

📉 Collagen and elastin loss: As early as age 25, production of these proteins declines by 1–2% per year. The skin loses its structural firmness and elasticity. Collagen is the skin's support scaffold – less collagen means more wrinkles. (Study: Varani J. et al. (2006) ,Rittie L. & Fischer G.J. 2015)

 

💧 Moisture deficiency & weakened skin barrier: With increasing age the skin produces fewer of its own lipids and loses moisture. The skin barrier weakens, so water evaporates faster. The result: dry skin that makes wrinkles more visible.

 

🌞 UV damage & oxidative stress: Studies show that up to 80% of skin aging is caused by UV radiation. UV rays destroy collagen fibers, promote pigment spots and make the skin appear slack. (Source: Salminen A. et al. 2022) 

 

🔄 Slowed cell renewal: While young skin renews itself every 28 days, older skin can take up to 50 days. This makes the skin lose radiance and wrinkles etch in more deeply. The result: dull, uneven skin that loses its glow.

 

⚖️ Glycation – the "sugar wrinkles": An underestimated process of skin aging is glycation – sugar molecules bind to collagen and elastin fibers and make them rigid and brittle. This leads to a slack, crepey skin structure.

 

🥶 Temperature stress & environmental exposure: Cold winter air, dry heated air or air pollution stress the skin barrier and accelerate wrinkle formation.

 

If skin aging is influenced by so many factors, does that mean we simply have to accept the aging process without being able to do anything about it? No! Because here's the decisive point: modern science shows that our skin can regenerate very well and we can significantly slow skin aging and visibly reduce existing wrinkles – if we deliberately supply it with the right active ingredients. Studies show that high-quality and the right active ingredients can demonstrably stimulate skin renewal, smooth wrinkles and improve skin structure. (Source: Griffiths, T.W. et al. 2023)

 

But why do so many people use the wrong products or achieve no visible results?

Marketing, advertising promises and decades of innovation failure across an entire industry – the most common mistakes in anti-aging skincare and how they accelerate skin aging

Driven by scientifically questionable advertising promises, many people rely on wrong or incomplete skincare routines & ingredients that do more harm than good in the long run. We asked scientist and skin expert Dr. Lars Rüther about the most common misconceptions and mistakes in anti-aging skincare:

 

Ingredients that are too aggressive: Many anti-aging products rely on aggressive peels or alcohol-based (monohydric alcohol) formulas that weaken the skin barrier and lead to dryness lines over time.
Better: Less is usually more. Avoid aggressive peels or too-frequent exfoliation as well as monohydric alcohols.

Dr. Lars Rüther is a molecular, cell and neurobiologist and an expert in skin aging and cell renewal. Dr. Rüther was head of research for 10 years at the renowned dermatological testing institute Dermatest. He has spent years studying skin aging, skin problems and the question of what effect active ingredients have on our skin cells. Dr. Rüther says: "Many products rely on short-term effects, on a kind of masking of wrinkles, but only few work at the root of the problem, directly at the cellular level"

One-size-fits-all solutions instead of personalized care: Every skin is different and it's our most dynamic organ. The wrong ingredients at the wrong time can cause irritation or simply not work. Skin needs care precisely tailored to its needs at the right time. Care recommended for all skin conditions can't specifically treat individual problems.
Better: Scientifically based, personalized skincare 

 

Cleansing that's too aggressive with drying surfactants: Many foaming cleansers contain sulfates (e.g. Sodium Lauryl Sulfate) that weaken the skin barrier. The result: moisture loss and dryness lines.
Better: Mild, replenishing cleansing with oils

 

No daily sun care: UV rays are responsible for up to 80% of visible skin aging. Even on cloudy days UV radiation penetrates the skin and damages collagen.
Better: Daily SPF (at least SPF 30), regardless of the weather.

 

Peels too frequent or too aggressive: Peels with high concentrations of acids or coarse abrasive particles can irritate the skin and lead to inflammation and premature skin aging.
Better: Use mild fruit-acid peels (AHA/BHA) at most 1–2 times per week.

 

Using too many or unsuitable products at once: Constantly switching products or combining too many ingredients risks skin irritation and a weakened skin barrier.
Better: Use few, well-coordinated products with targeted, effective ingredients.

 

Moisturizing without skin-strengthening lipids: Many anti-aging creams contain only hydrating substances (e.g. hyaluronic acid) but no skin-strengthening lipids like ceramides, squalane or omega fatty acids.
Better: Choose care products that combine moisture and lipids to stabilize the skin's protective barrier.

 

Using vitamin C and retinol incorrectly: Vitamin C loses its effect when stored improperly (e.g. exposed to light or air). Retinol can make the skin more sensitive if no sun protection is used.
Better: Vitamin C stabilized with gold atoms and encapsulated retinol and always combine with sun protection.

 

Forgetting to remove makeup or wearing makeup overnight: Makeup residue and dirt particles can promote oxidative stress and hinder the skin's regeneration process.
Better: Thorough but gentle makeup removal, ideally with an oil-based cleanser or combined with a second mild cleanser (double cleansing)

 

Drinking too little water: Too little water dehydrates the skin from within
Better: About 2 liters of water per day, adjusted to activity and ambient temperature.

 

Poor diet with too much sugar and processed foods: High sugar consumption leads to glycation, in which collagen fibers harden and wrinkles form.
Better: Incorporate more antioxidants, omega fatty acids and proteins into your diet.

 

Ignoring stress and lack of sleep: Cortisol (the stress hormone) promotes the breakdown of collagen and elastin. Less sleep means less cell regeneration.
Better: 7–9 hours of sleep per night and targeted relaxation techniques like meditation or yoga.

"Skin aging is no accident. The right skincare and a conscious lifestyle can visibly slow the process."

- Dr. Lars Rüther

🔬 The solution? A precisely tailored skincare routine with scientifically based active-ingredient combinations.

Dr. Viktor Balzer presents research findings on skinmade at the Fraunhofer network symposium, Munich 2020

Scientific research as the solution – the emergence of a new skincare technology – personalized skincare at the cellular level

 

While skin aging is influenced by many biological and external factors, the question of how to effectively slow this process long remained unanswered. Many skincare products promise visible anti-aging effects, yet their formulations are often based on outdated concepts or contain active ingredients in the wrong concentrations and combinations to actually achieve lasting effects. 

 

To tackle this problem scientifically, researchers at the renowned Fraunhofer Institute began an intensive investigation of skin aging in 2013 and developed a completely new care concept - skinmade®. Their goal: a care system that doesn't just hydrate on the surface but penetrates deep into the skin to fight skin aging there at the root, at the cellular level.

 

The breakthrough in dermatological research: the 3 key findings

 

🔬 1. The right active ingredients in the right concentration
In long-term studies, the Fraunhofer researchers were able to prove that certain bioactive ingredients activate skin regeneration and slow collagen breakdown. These include:

Peptides & Epidermal Growth Factors (EGF)
Studies show that peptides and EGFs specifically boost collagen and elastin production by up to 70%, promote cell regeneration and thereby visibly firm the skin. In clinical studies, peptides and EGFs showed a significant reduction of wrinkles after 8 weeks. (Source: Salvador Ferreira M. et al. 2020)

Retinol & Bakuchiol
Retinol is one of the best-researched anti-aging ingredients. It stimulates cell regeneration, smooths and thickens the skin structure and reduces pigment spots. Bakuchiol is a gentle, plant-based alternative with a similar effect but without potential irritation. Proven cell activators that accelerate skin renewal and smooth wrinkles from within.

Hyaluronic acid & moisture-retaining lipids
Hyaluronic acid draws water into the skin cells and plumps them up – for a plumper, smoother complexion. Lipids support the skin barrier and prevent moisture loss. Hyaluronic acid plumps the skin from within and lipids strengthen the skin barrier and prevent moisture loss.

Antioxidants & Niacinamide (Vitamin B3)
These active ingredients fight free radicals, protect the skin cells from UV damage and prevent DNA damage in the skin. Niacinamide strengthens the skin's protective barrier and reduces fine lines.

Omega fatty acids & ceramides
They repair the skin barrier and help the skin retain moisture – a decisive factor against dryness lines.

Squalane 
Squalane is a skin-identical lipid that penetrates deep into the skin and stores moisture there. It acts as a natural antioxidant, prevents moisture loss and protects the skin barrier. Studies show that squalane can improve skin elasticity and reduce dryness lines. (Source: Kim K.S. & Karadeniz F., 2012)

Sun protection & repair enzymes
Without UV protection, even the best anti-aging care is useless. Enzymes help repair UV damage that has already occurred.

💡 Finding: It's not the active ingredient alone that determines effectiveness, but also its concentration and combination.

 

🔬 2. The skin can only use active ingredients effectively if they penetrate deeply. A common problem with many skincare products is that the active ingredients stay on the skin surface and don't penetrate deeply enough to achieve lasting effects.

 

The researchers developed innovative penetration systems that specifically transport bioactive and biomimetic ingredients into deeper skin layers. This allows:

Collagen to be formed exactly where it's needed.

Moisture to reach deeper skin structures to enable long-lasting plumping of the skin.

Protection from UV and environmental stress to take place directly at the cellular level.

Green = collagen (fluorescence microscopy)

 

Control group: without vitamin C application

Green = collagen (fluorescence microscopy)

 

Subjects A: vitamin C application

Green = collagen (fluorescence microscopy)

 

Subjects B: vitamin C application stabilized with gold atoms for deeper skin penetration

 

Collagen synthesis is 100% more effective than with plain vitamin C

💡 Finding: Only when active ingredients penetrate deep enough into the skin can they truly work against skin aging.

 

🔬 3. Less is more: the minimalist but effective care routine
Many people overload their skin with numerous products that often aren't coordinated with one another. The Fraunhofer research showed that a reduced but precisely tailored skincare is more effective than, for example, complicated 10-step routines.

 

The solution: as much care as necessary, but as little as possible.

 

🧴 Gentle, replenishing cleansing so as not to destroy the skin barrier.

💧 Targeted active-ingredient serums to effectively slow skin aging.

🌿 Individually tailored moisturizing care that contains exactly the ingredients needed.

☀️ Daily UV protection to prevent light-induced skin aging.

"I recommend using sun protection daily, even in winter, with at least SPF 30 – but preferably SPF 50 – high UVA protection and antioxidants."

- Dr. Lars Rüther

💡 Finding: Excessive skincare can overwhelm the skin. A minimalist but highly effective routine delivers the best results in the long run.

 

The result: scientifically based skincare that effectively reduces wrinkles

 

The research clearly shows: skin aging is not an unavoidable process but the result of biological and environmental factors that can be specifically influenced. Through the right combination of highly effective bioactive ingredients, deep-acting penetration systems and a minimalist but highly efficient care routine, the skin's natural aging process can be slowed and wrinkles visibly reduced.

While many conventional care products rely on short-term effects, clinical studies prove that an evidence-based skincare strategy with individually tailored active ingredients leads to better results in the long run.

Based on these findings, the personalized, biomimetic system care skinmade® was developed, integrating the latest scientific research findings. This method has been tested in clinical studies and has shown that individually tailored skincare:

✔️ Reduces fine lines and wrinkles

✔️ Promotes collagen and elastin production

✔️ Strengthens the skin barrier and prevents moisture loss

✔️ Minimizes harmful effects of UV radiation and free radicals

Before
After

Before-and-after image of the eye after 8 weeks of skinmade use

Before
After

Before-and-after image after 12 weeks of skinmade use

The development of skinmade® is based on over 10 years of research at the Fraunhofer Institute, one of Europe's leading scientific institutions for applied skin research. skinmade® has been tested in clinical studies and the innovation has won multiple awards – including the Baden-Württemberg Founder's Award.

Minister of Economic Affairs Nicole Hoffmeister-Kraut presents Dr. Viktor Balzer with the Baden-Württemberg Founder's Award for the development and founding of skinmade, Stuttgart 2018

Choosing the right skincare is a decision for long-term skin health and fewer wrinkles. Anyone who wants to specifically combat skin aging benefits from scientifically tested active-ingredient combinations and care that demonstrably supports cell regeneration, stimulates collagen synthesis and optimizes the skin's moisture balance.

 

🔬 Find more information about the scientifically based skincare skinmade and ordering options here: 

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The research has proven: effective skincare can do more than just provide surface moisture – it can specifically slow skin aging and visibly reduce wrinkles.

Testimonials: what customers say about skinmade®'s effect on wrinkles and moisture

Numerous users report their positive experiences with the personalized skincare from skinmade® – especially when it comes to reducing wrinkles, improving skin elasticity and optimal moisture supply.

⭐️⭐️⭐️⭐️⭐️ Monika S. (52 years)

"I've tried so many anti-aging creams, but none has changed my skin like skinmade®. After just a few weeks it feels firmer, and the fine lines around my eyes are less visible. I never thought personalized skincare could make such a difference!"

⭐️⭐️⭐️⭐️⭐️ Claudia (48 years)

I'm happy 😊 I have fewer wrinkles, especially around the eyes"

⭐️⭐️⭐️⭐️⭐️ Sabine K. (45 years)

"I'm convinced! My forehead wrinkles look much softer, my complexion is more radiant and overall my skin feels firmer. I'm truly thrilled!"

⭐️⭐️⭐️⭐️⭐️ Alexander R. (55 years)

"My skin isn't as dry anymore and looks fresher. I even get compliments that I look rested and healthier!"

 

These responses show that skinmade®'s scientifically based, personalized skincare offers a lasting solution for visible signs of skin aging. Instead of relying on generic solutions, the skin is supplied with exactly the active ingredients it truly needs – with clinically proven effect.

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