The Fight Against Wrinkles - Rejuvenation is the Latest Trend in Skincare

Does Skincare Really Help Against Wrinkles? What Science Says

February 11, 2025

Wrinkles – An Unavoidable Process or Controllable After All?

Few topics concern people over 30 as much as skin aging. The first glance in the mirror in the morning often shows it mercilessly: fine lines around the eyes, forehead wrinkles, crinkles on the décolleté – they seem to become more visible day by day. Every person experiences the natural aging process of the skin. But the speed and extent to which wrinkles develop is not solely genetically determined. External factors such as UV radiation, oxidative stress, and moisture loss play a crucial role.

Many people have already spent a lot of money on a variety of anti-aging products – without visible success. The market is full of creams and serums that promise short-term effects but often show no lasting impact. So the big question remains: Can skincare really reduce wrinkles?

Scientists at Fraunhofer IPA conduct research on skinmade, Stuttgart 2018

Many believe that skin aging is solely genetic and that cosmetic products only provide short-term effects. Others think that moisture alone is enough to prevent wrinkles. The answer lies in science. After more than 10 years of intensive research at the renowned Fraunhofer Institute, one of Europe's leading research institutions, a completely new skincare approach was developed with skinmade®: Personalized care with scientifically proven active ingredient complexes & penetration systems can visibly slow down the aging process and reduce existing wrinkles.

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But why do wrinkles appear in the first place? And which approaches are truly effective?

Why do wrinkles form – and what factors accelerate skin aging?

Wrinkles are caused by a combination of genetic predisposition and environmental factors. While our genes determine how quickly our skin ages, external factors play a crucial role in wrinkle formation. Wrinkles are the visible result of a combination of several biological processes that occur in the skin. While genetic predisposition plays a role, it is primarily external influences and lifestyle that determine how quickly wrinkles form and how deep they are.

 

📉 Loss of collagen and elastin: As early as age 25, the production of these proteins decreases by 1–2% annually. The skin loses its structural firmness and elasticity. Collagen is the skin's scaffold – less collagen means more wrinkles. (Study: Varani J. et al. (2006) ,Rittie L. & Fischer G.J. 2015)

 

💧 Lack of moisture & weakened skin barrier: With increasing age, the skin produces fewer of its own lipids and loses moisture. The skin barrier weakens, causing water to evaporate more quickly. The result: dry skin that makes wrinkles more visible.

 

🌞 UV damage & oxidative stress: Studies show that up to 80% of skin aging is caused by UV radiation. UV rays destroy collagen fibers, promote pigment spots, and make the skin appear saggy. (Source: Salminen A. et al. 2022) 

 

🔄 Slowed cell renewal: While young skin renews itself every 28 days, it can take up to 50 days for older skin. This causes the skin to lose its radiance and wrinkles to become deeper. The result: dull, uneven skin that loses its radiance.

 

⚖️ Glycation – The "sugar wrinkles": An underestimated process of skin aging is glycation – sugar molecules bind to collagen and elastin fibers, making them stiff and brittle. This leads to a sagging, wrinkled skin structure.

 

🥶 Temperature stress & environmental pollution: Cold winter air, dry heating air, or air pollution strain the skin barrier and accelerate wrinkle formation.

 

If skin aging is influenced by so many factors, does that mean we simply have to accept the aging process without being able to do anything about it? No! Because here comes the crucial point: Modern science shows that our skin can regenerate very well, and we can significantly slow down skin aging and visibly reduce existing wrinkles – if we specifically supply it with the right active ingredients. Studies show that high-quality and the right active ingredients can demonstrably stimulate skin renewal, smooth wrinkles, and improve skin structure. (Source: Griffiths, T.W. et al. 2023)

 

But why do so many people use the wrong products or achieve no visible results?

Marketing, advertising promises and decades of innovation failure across an entire industry – the most common mistakes in anti-aging skincare and how they accelerate skin aging

Driven by scientifically questionable advertising claims, many people rely on incorrect or incomplete skincare routines & ingredients that ultimately do more harm than good. We asked scientist and skin expert Dr. Lars Rüther about the most common misconceptions and mistakes in anti-aging skincare:

 

Overly aggressive ingredients: Many anti-aging products use aggressive exfoliants or alcohol-based (monohydric alcohols) formulas that weaken the skin barrier and ultimately lead to dry fine lines.
Better: Less is usually more. Avoid aggressive or overly frequent exfoliation, as well as monohydric alcohols.

Dr. Lars Rüther is a molecular, cell and neurobiologist and an expert in skin aging and cell regeneration. Dr. Rüther was head of research at the renowned dermatological testing institute Dermatest for 10 years. For years, he has been involved with skin aging, skin problems and the question of what effect active ingredients have on our skin cells. Dr. Rüther says: "Many products focus on short-term effects, on a kind of camouflage for wrinkles, but only a few work at the root of the problem, directly at the cellular level"

One-size-fits-all solutions instead of personalized care: Every skin is different, and it is our most dynamic organ. The wrong ingredients at the wrong time can cause irritation or simply not work. Skin needs care that is precisely tailored to its needs at the right time. Care that is recommended for all skin conditions cannot specifically address individual problems.
Better: Scientifically sound, personalized skincare 

 

Overly aggressive cleansing with drying surfactants: Many foaming cleansing products contain sulfates (e.g., Sodium Lauryl Sulfate), which weaken the skin barrier. The result: moisture loss and dehydration lines.
Better: Gentle, re-hydrating cleansing with oils

 

No daily sun protection: UV rays are responsible for up to 80% of visible skin aging. Even on cloudy days, UV radiation penetrates the skin and damages collagen.
Better: Daily sun protection factor (at least SPF 30), regardless of the weather.

 

Too frequent or aggressive exfoliation: Exfoliants with high concentrations of acids or coarse abrasive particles can irritate the skin and lead to inflammation and premature skin aging.
Better: Use mild fruit acid peels (AHA/BHA) a maximum of 1-2 times per week.

 

Using too many or unsuitable products simultaneously: Constantly changing products or combining too many ingredients risks skin irritation and a weakened skin barrier.
Better: Use a few well-matched products with specifically effective ingredients.

 

Moisturizer without skin-strengthening lipids: Many anti-aging creams contain only moisturizing substances (e.g., hyaluronic acid) but no skin-strengthening lipids such as ceramides, squalane, or omega fatty acids.
Better: Choose skincare products that combine moisture and lipids to stabilize the skin's protective barrier.

 

Incorrect application of Vitamin C and Retinol: Vitamin C loses its effectiveness if stored incorrectly (e.g., exposure to light or air). Retinol can make the skin more sensitive if sunscreen is not used.
Better: Use Vitamin C stabilized with gold atoms and encapsulated Retinol, and always combine with sun protection.

 

Forgetting to remove makeup or wearing makeup overnight: Makeup residues and dirt particles can promote oxidative stress and hinder the skin's regeneration process.
Better: Thorough but gentle makeup removal, ideally with an oil-based cleanser or in combination with a second mild cleanser (double cleansing)

 

Not drinking enough water: Insufficient water dehydrates the skin from within.
Better: Approx. 2 liters of water per day, adjusted for activity and ambient temperature.

 

Poor diet with too much sugar and processed foods: High sugar consumption leads to glycation, where collagen fibers harden and wrinkles form.
Better: Incorporate more antioxidants, omega fatty acids, and proteins into your diet.

 

Ignoring stress and lack of sleep: Cortisol (the stress hormone) promotes the breakdown of collagen and elastin. Less sleep means less cell regeneration.
Better: 7-9 hours of sleep per night and targeted relaxation techniques such as meditation or yoga.

"Skin aging is no accident. The right skincare and a conscious lifestyle can visibly slow down the process."

- Dr. Lars Rüther

🔬 The solution? A precisely tailored skincare routine with scientifically proven active ingredient combinations.

Dr. Viktor Balzer presents research findings on skinmade at the Fraunhofer Network Symposium, Munich 2020

Scientific Research as a Solution – The Emergence of a New Skincare Technology – Personalized Skincare at the Cellular Level

 

While skin aging is influenced by many biological and external factors, the question of how to effectively slow down this process remained unanswered for a long time. Many skincare products promise visible anti-aging effects, but their formulations are often based on outdated concepts or contain active ingredients in incorrect concentrations and combinations to achieve truly long-term effects.

 

To address this problem scientifically, researchers at the renowned Fraunhofer Institute began an intensive investigation into skin aging in 2013, developing an entirely new skincare concept – skinmade®. Their goal: a skincare system that not only moisturizes superficially but also penetrates deep into the skin to combat skin aging at its root, at the cellular level.

 

The Breakthrough of Dermatological Research: The 3 Key Findings

 

🔬 1. The right active ingredients in the right concentration
Fraunhofer researchers were able to demonstrate in long-term studies that certain bioactive ingredients activate skin regeneration and slow down collagen breakdown. These include:

Peptides & Epidermal Growth Factors (EGF)
Studies show that peptides and EGFs specifically increase collagen and elastin production by up to 70%, promote cell regeneration, and thus visibly firm the skin. In clinical studies, peptides and EGFs showed a significant reduction in wrinkles after 8 weeks. (Source: Salvador Ferreira M. et al. 2020)

Retinol & Bakuchiol
Retinol is one of the most thoroughly researched anti-aging active ingredients. It stimulates cell regeneration, smooths and thickens the skin's structure, and reduces hyperpigmentation. Bakuchiol is a gentle, plant-based alternative with similar effects but without potential irritation. These are proven cell activators that accelerate skin renewal and smooth wrinkles from within.

Hyaluronic Acid & Moisture-Retaining Lipids
Hyaluronic acid draws water into skin cells, plumping them up for a fuller, smoother complexion. Lipids support the skin barrier and prevent moisture loss. Hyaluronic acid plumps the skin from within, and lipids strengthen the skin barrier, preventing moisture loss.

Antioxidants & Niacinamide (Vitamin B3)
These active ingredients fight free radicals, protect skin cells from UV damage, and prevent DNA damage in the skin. Niacinamide strengthens the skin's protective barrier and reduces fine lines.

Omega Fatty Acids & Ceramides
They repair the skin barrier and help the skin retain moisture – a crucial factor against dehydration lines.

Squalane 
Squalanes are skin-identical lipids that penetrate deep into the skin and store moisture there. They act as natural antioxidants, prevent moisture loss, and protect the skin barrier. Studies show that squalanes can improve skin elasticity and reduce dry lines. (Source: Kim K.S. & Karadeniz F., 2012)

Sun Protection & Repair Enzymes
Without UV protection, even the best anti-aging care is useless. Enzymes help repair existing UV damage.

💡 Insight: It's not just the active ingredient that determines effectiveness, but also its concentration and combination.

 

🔬 2. The skin can only effectively utilize active ingredients if they penetrate deeply. A common problem with many skincare products is that the active ingredients remain on the skin's surface and do not penetrate deeply enough to achieve lasting effects.

 

The researchers developed innovative penetration systems that specifically transport bioactive and biomimetic active ingredients into deeper skin layers. This allows for:

collagen to be formed exactly where it is needed.

moisture to penetrate deeper skin structures, allowing for long-lasting plumping of the skin.

protection from UV and environmental damage takes place directly at the cellular level.

Green = Collagen (Fluorescence Microscopy)

 

Control group: No vitamin C applied

Green = Collagen (fluorescence microscopy)

 

Subjects A: Vitamin C application

Green = Collagen (Fluorescence Microscopy)

 

Subjects B: Application of Vitamin C stabilized with gold atoms for deeper skin penetration

 

Collagen synthesis is 100% more effective than with simple Vitamin C

💡 Insight: Active ingredients can only truly combat skin aging if they penetrate deep enough into the skin.

 

🔬 3. Less is more: The minimalist yet effective skincare routine
Many people overload their skin with numerous products that are often not compatible with each other. Fraunhofer research showed that a reduced, but precisely tailored skincare routine is more effective than, for example, complicated 10-step routines.

 

The solution: As much care as necessary, but as little as possible.

 

🧴 Gentle, re-fattening cleansing so as not to destroy the skin barrier.

💧 Targeted active ingredient serums to effectively slow down skin aging.

🌿 Individually tailored moisturizing care that contains exactly the necessary ingredients.

☀️ Daily UV protection to prevent light-induced skin aging.

"I recommend using sunscreen daily, even in winter, with at least SPF 30, but preferably SPF 50, high UVA protection, and antioxidants."

- Dr. Lars Rüther

💡 Insight: Excessive skincare can overwhelm the skin. A minimalist yet highly effective routine yields the best long-term results.

 

The result: Scientifically sound skincare that effectively reduces wrinkles

 

Research clearly shows that skin aging is not an unavoidable process, but rather the result of biological and environmental factors that can be specifically influenced. Through the right combination of highly effective bioactive ingredients, deeply penetrating delivery systems, and a minimalist yet highly efficient care routine, the skin's natural aging process can be slowed down and wrinkles visibly reduced.

While many conventional skincare products focus on short-term effects, clinical studies prove that an evidence-based skincare strategy with individually tailored active ingredients leads to better long-term results.

Based on these insights, the personalized, biomimetic system care skinmade® was developed, integrating the latest scientific research findings. This method has been tested in clinical studies and has shown that individually tailored skincare can:

✔️ Reduce fine lines and wrinkles

✔️ Promote collagen and elastin production

✔️ Strengthen the skin barrier and prevent moisture loss

✔️ Minimize the harmful effects of UV radiation and free radicals

Prior to
After

Before & After image of the eye after 8 weeks of skinmade application

Prior to
After

Before & After picture after 12 weeks of skinmade application

The development of skinmade® is based on over 10 years of research at the Fraunhofer Institute, one of Europe's leading scientific institutions for applied skin research. skinmade® has been tested in clinical studies and the innovation has received multiple awards – including the Baden-Württemberg Founder's Award.

Minister of Economic Affairs Nicole Hoffmeister-Kraut presents Dr. Viktor Balzer with the Baden-Württemberg Founder's Award for the development and founding of skinmade, Stuttgart 2018

Choosing the right skincare is a decision for long-term skin health and fewer wrinkles. Those who want to specifically combat skin aging benefit from scientifically proven active ingredient combinations and a skincare that demonstrably supports cell regeneration, stimulates collagen synthesis, and optimizes the skin's moisture balance.

 

🔬 Further information on scientifically-based skinmade skincare and ordering options can be found here: 

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Research has shown: Effective skincare can do more than just provide superficial moisture – it can specifically slow down skin aging and visibly reduce wrinkles.

Testimonials: What customers say about the effect of skinmade® on wrinkles and moisture

Numerous users report positive experiences with skinmade® personalized skincare – especially when it comes to reducing wrinkles, improving skin elasticity, and optimal hydration.

⭐️⭐️⭐️⭐️⭐️ Monika S. (52 years old)

"I've tried so many anti-aging creams, but none have transformed my skin like skinmade®. After just a few weeks, it feels firmer, and the fine lines around my eyes are less visible. I never thought personalized skincare could make such a difference!"

⭐️⭐️⭐️⭐️⭐️ Claudia (48 years old)

"I'm happy 😊 I have fewer wrinkles, especially around my eyes."

⭐️⭐️⭐️⭐️⭐️ Sabine K. (45 years old)

"I'm convinced! My forehead wrinkles look much softer, my complexion is more radiant, and overall my skin feels firmer. I'm truly impressed!"

⭐️⭐️⭐️⭐️⭐️ Alexander R. (55 years old)

"My skin is no longer so dry and looks fresher. I even get compliments that I look rested and healthier!"

 

These feedbacks demonstrate that skinmade®'s scientifically-based, personalized skincare offers a sustainable solution for visible signs of skin aging. Instead of relying on generic solutions, the skin is supplied with exactly the active ingredients it truly needs – with clinically proven efficacy.

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